Retinol binding protein 4 (human), mouse monoclonal | Toronto BioScience 21060 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Retinol binding protein 4 (human), mouse monoclonal

catalog :

21060

quantity :

100 μg

price :

194 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5H9

reactivity :

human

more info or order :

Toronto BioScience product webpage

citations: 4

Reference
Chen C, Wu J, Chang C, Tsai F, Wang T, Liu Y, et al. Levels of retinol-binding protein 4 and uric acid in patients with type 2 diabetes mellitus. Metabolism. 2009;58:1812-6 pubmed publisher
Suh J, Kim S, Cho G, Choi K, Han J, Taek Geun H. Elevated serum retinol-binding protein 4 is associated with insulin resistance in older women. Metabolism. 2010;59:118-22 pubmed publisher
Motani A, Wang Z, Conn M, Siegler K, Zhang Y, Liu Q, et al. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J Biol Chem. 2009;284:7673-80 pubmed publisher
Henze A, Frey S, Raila J, Tepel M, Scholze A, Pfeiffer A, et al. Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels. Diabetes. 2008;57:3323-6 pubmed publisher

product information

Catalog Number :

21060

Product Name :

Retinol binding protein 4 (human), mouse monoclonal

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

194 USD

list of Pubmed id :

19766271, 19709697, 18796616, 19147488

Clone :

5H9

Isotype :

Mouse IgG

Product Description :

this mouse monoclonal antibody can be used as a capture antibody in a human retinol binding protein 4 ELISA in combination with monoclonal anti-human retinol binding protein 4 antibody (Cat. No.: 21061)

SpeciesSummary :

Human specificity

Background :

Retinol binding protein 4 (RBP4), originally known as a specific transport of retinol in blood, is also a novel inflammatory and insulin resistance marker. Serum RBP4 levels are elevated in insulin-resistant mice and humans with obesity and type 2 diabetes. Animal experiments found that increased secretion of RBP4 might reduces insulin-dependent glucose uptake by muscle tissue by reducing the activity of PI(3)K (phosphoinositide 3-kinase), and increased hepatic glucose output by increasing the expression of the enzyme PEPCK2. Studies suggested that elevated serum RBP4 was associated with components of the metabolic syndrome, including increased body-mass index, waist-to-hip ratio, serum triglyceride levels, and systolic blood pressure and decreased high- density lipoprotein cholesterol levels. Furthermore, circulating RBP4 concentrations were associated with subclinical cardiovascular disease, which imply that RBP4 could be involved in the development of atherosclerosis.

ALTnames :

Retinol binding protein (RBP4) is also known as 4RDCCAS and MCOPCB10

Immunogen :

E. coli derived recombinant human RBP4 (Cat. No. 41060)

Specificity :

Human

Buffer :

Solution in PBS

Uses :

ELISA - capture antibody

Application Summary :

This antibody can be used as a capture antibody in a human retinol binding protein 4 ELISA in combination with monoclonal anti-human retinol binding protein 4 antibody (Cat. No.: 21061)

Storage :

Store at –20°C.

General References :

1.The metabolic role of retinol binding protein 4: an update. Christou GA, Tselepis AD, Kiortsis DN. Horm Metab Res. 2012 44(1):6-14. 2. RBP4: a controversial adipokine. Kotnik P, Fischer-Posovszky P, Wabitsch M. Eur J Endocrinol. 2011 Nov;165(5):703-11

Product References :

Journal of Clinical Endocrinology & Metabolism 2012 [97(12):4701-8]; PLoS One 2013 [8(6):e66607]; PLoS One. 2014 May 6;9(5):e96489;

more info or order :

Toronto BioScience product webpage