Lipocalin 2 (human), mouse monoclonal | Toronto BioScience 21050 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Lipocalin 2 (human), mouse monoclonal

catalog :

21050

quantity :

100 μg

price :

194 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2G1

reactivity :

human

more info or order :

Toronto BioScience product webpage

citations: 4

Reference
Srisawat N, Praditpornsilpa K, Patarakul K, Techapornrung M, Daraswang T, Sukmark T, et al. Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand. PLoS ONE. 2015;10:e0143367 pubmed publisher
Chan Y, Liu J, Pociask D, Zheng M, Mietzner T, Berger T, et al. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol. 2009;182:4947-56 pubmed publisher
Xu G, Ahn J, Chang S, Eguchi M, Ogier A, Han S, et al. Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation. J Biol Chem. 2012;287:4808-17 pubmed publisher
Leng X, Ding T, Lin H, Wang Y, Hu L, Hu J, et al. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res. 2009;69:8579-84 pubmed publisher

product information

Catalog Number :

21050

Product Name :

Lipocalin 2 (human), mouse monoclonal

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

194 USD

list of Pubmed id :

22117066, 26629810, 19887608, 19342674

Clone :

2G1

Isotype :

Mouse IgG1

Product Description :

This affinity purified mouse monoclonal antibody can be used as a capture antibody in a human Lipocalin-2 ELISA in combination with monoclonal anti-human Lipocalin-2 antibody clone 2C3 (Cat. No: 21051).

SpeciesSummary :

Human specificity

Background :

Lipocalin-2(LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), 24p3, or neutrophil lipocalin (NL), is a 25-kDa secretory glycoprotein1. LCN2 has been implicated in a variety of cellular processes including the innate immune response, differentiation, tumorigenesis, and cell survival2,3. It appears to be upregulated in various inflammation and infection conditions. Several reports suggest4 that LCN2 may represent a sensitive biomarker for various renal injuries and is associated with several types of cancers, including breast cancer5, ovarian, colorectal, and pancreatic cancers6,7. Furthermore, a growing body of evidence suggests that serum levels of lipocalin-2 are correlated with obesity, insulin resistance, hyperglycemia, coronary heart disease and fatty liver disease in humans8-11.

ALTnames :

Lipocalin-2(LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), 24p3, or neutrophil lipocalin (NL)

Immunogen :

E.coli-derived recombinant human lipocalin-2 (Cat. No: 41050).

Specificity :

Human

Buffer :

Solution in PBS

Uses :

ELISA - capture antibody

Application Summary :

This antibody can be used as a capture antibody in a human Lipocalin-2 ELISA in combination with monoclonal anti-human Lipocalin-2 antibody clone 2C3 (Cat. No: 21051).

Storage :

Store at –20°C.

General References :

[1] Kjeldsen, L. et al. (1993) J. Biol. Chem. 268:10425-32 [2] Yang, J. et al. (2002) Mol. Cell. 10:1045-56. [3] Flo, T.H. et al. (2004) Nature 432:917-21. [4] Mishra, J. et al. (2005) Lancet 365:1231-6. [5] Yang, J. et al. (2009) Proc Natl Acad Sci U S A 106(10):3913-8. [6] Hanai, J. et al. (2005) J. Biol. Chem. 280:13641-7. [7] Lee, H.J. et al. (2005) Int. J. Cancer 118:2490-7. [8] Wang Y, et al. (2007) Clin Chem 53(1):34-41. [9] Yan QW, et al. (2007) Diabetes 56(10):2533-40. [10] Ruby LC Hoo, et al. (2008) Expert Rev. Endocrinol Metal 3(1):29-41. [11] Milner KL, et al. Hepatology [Epub ahead of print]

Product References :

PLoS One 2013 [8(6):e66607], Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2457-64

more info or order :

Toronto BioScience product webpage