Fatty-acid binding protein 4 (A-FABP) (human), mouse monoclonal | Toronto BioScience 21030 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Fatty-acid binding protein 4 (A-FABP) (human), mouse monoclonal

catalog :

21030

quantity :

100 μg

price :

220 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2C11

reactivity :

human

application :

ELISA

more info or order :

Toronto BioScience product webpage

citations: 3

Reference
Steen K, Xu H, Bernlohr D. FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2. Mol Cell Biol. 2016;: pubmed
Furuhashi M, Hiramitsu S, Mita T, Fuseya T, Ishimura S, Omori A, et al. Reduction of serum FABP4 level by sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes mellitus. J Lipid Res. 2015;56:2372-80 pubmed publisher
Li Y, Li X, Dong Z. Concerted dynamic motions of an FABP4 model and its ligands revealed by microsecond molecular dynamics simulations. Biochemistry. 2014;53:6409-17 pubmed publisher

product information

Catalog Number :

21030

Product Name :

Fatty-acid binding protein 4 (A-FABP) (human), mouse monoclonal

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

220 USD

list of Pubmed id :

26467280, 27795298, 25231537

Clone :

2C11

Isotype :

Mouse IgG

Product Description :

This mouse monoclonal antibody against human fatty-acid binding protein 4 (FABP4) can be used to detect human FABP4 by ELISA.

SpeciesSummary :

Human specificity

Background :

Fatty-acid binding protein 4 (FABP4), also termed adipocyte fatty-acid binding protein (A-FABP), or aP2, is a novel adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP-4 plays a key role in the link between obesity and various features of metabolic syndrome. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. Studies in human found FABP-4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop a metabolic syndrome and type 2 diabetes. Additionally, serum FABP-4 levels were associated with nonalcoholic fatty liver disease, carotid atherosclerosis and coronary artery disease.

ALTnames :

Fatty acid binding protein 4 (FABP4) is also known as aP2; ALBP; AFABP; A-FABP; HEL-S-104.

Immunogen :

Recombinant full-length human FABP4 expressed in E.coli.

Specificity :

Human

Buffer :

Solution in PBS

Uses :

ELISA - This antibody can be used in ELISA with the appropriate secondary reagents to detect human FABP4

Application Summary :

ELISA - This antibody can be used in ELISA with the appropriate secondary reagents to detect human FABP4

Storage :

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

General References :

[1] Furuhashi M, et al. (2015) J Lipid Res; 56(12):2372-80. [2] Steen KA, et al. (2016) Mol Cell Biol; pii: MCB.00282-16. [Epub ahead of print] [3] Li Y, et al. (2014) Biochemistry; 53(40):6409-17.

Product References :

Journal of Clinical Endocrinology & Metabolism 2012 [97(12):4701-8]; Clinical Science 2013 [124(2):115-22]; Journal American Heart Association 2013 [2(1):e004176];

more info or order :

Toronto BioScience product webpage