Adiponectin (human), mouse monoclonal Ha6 | Toronto BioScience 21010 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Adiponectin (human), mouse monoclonal Ha6

catalog :

21010

quantity :

100 μg

price :

194 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Ha6

reactivity :

human

more info or order :

Toronto BioScience product webpage

citations: 5

Reference
Aye I, Rosario F, Powell T, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015;112:12858-63 pubmed publisher
Jahng J, Turdi S, Kovacevic V, Dadson K, Li R, Sweeney G. Pressure Overload-Induced Cardiac Dysfunction in Aged Male Adiponectin Knockout Mice Is Associated With Autophagy Deficiency. Endocrinology. 2015;156:2667-77 pubmed publisher
Liu Y, Sen S, Wannaiampikul S, Palanivel R, Hoo R, Isserlin R, et al. Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action. Biochem J. 2015;469:71-82 pubmed publisher
Liu Y, Palanivel R, Rai E, Park M, Gabor T, Scheid M, et al. Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice. Diabetes. 2015;64:36-48 pubmed publisher
Hui X, Gu P, Zhang J, Nie T, Pan Y, Wu D, et al. Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Cell Metab. 2015;22:279-90 pubmed publisher

product information

Catalog Number :

21010

Product Name :

Adiponectin (human), mouse monoclonal Ha6

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

194 USD

list of Pubmed id :

26417088, 26166748, 25915851, 25961840, 25071026

Clone :

Ha6

Isotype :

Mouse IgG

Product Description :

This affinity purified mouse monoclonal antibody can be used as a capture antibody in a human adiponectin ELISA in combination with monoclonal anti-human adiponectin antibody (Cat. No.: 21011).

CrossReactivity :

Not yet tested in other species.

SpeciesSummary :

Human specificity

Background :

As described in the product data sheet, adiponectin, also known as apM1, Acrp30, GBP28 and adipoQ, is a circulating hormone predominantly produced from adipose tissue. Many pharmacological studies demonstrated that this protein possesses potent anti-diabetic, anti-atherogenic and anti-inflammatory functions. Supplement of adiponectin protein can decrease blood glucose, improve insulin sensitivity, alleviate fatty liver and prevent atherosclerosis. The protein is posttranslationally modified by hydroxylation and glycosylation, and forms three different oligomeric complexes in the circulation. Many clinical studies demonstrated that plasma adiponectin is an useful biomarker for metabolic syndrome, nonalcoholic steatohepatitis and certain type of cancers. Decreased circulating levels of plasma adiponectin (hypoadiponectinaemia) are associated with increased body mass index (BMI), decreased insulin sensitivity, less favourable plasma lipid profiles, increased levels of inflammatory markers and increased risk for the development of type 2 diabetes, hypertension, and coronary heart diseases. Low adiponectin concentrations were found to be predictive of a future reduction in insulin sensitivity and cardiovascular disorders. Administration of the anti-diabetic drugs thiazolidinediones (TZDs) raises circulating adiponectin levels. In addition, low plasma adiponectin levels are also associated with nonalcoholic steatohepatitis (NASH) and certain types of cancers.

ALTnames :

Adiponectin is also known as apM1, Acrp30, GBP28 and adipoQ.

Immunogen :

HEK-293 derived recombinant human adiponectin (Cat. No. 41013)

Specificity :

Human

Buffer :

Solution in PBS

Uses :

This antibody can be used as a capture antibody in a human adiponectin ELISA in combination with monoclonal anti-human adiponectin antibody (Cat. No.: 21011)

Application Summary :

This antibody can be used as a capture antibody in a human adiponectin ELISA in combination with monoclonal anti-human adiponectin antibody (Cat. No.: 21011)

Storage :

Store at –20°C.

General References :

[1] Trujillo ME, Scherer PE. (2005) J Intern Med. 257:167-175. [2] Berg AH. et al. (2001) Nat Med. 7:947-953. [3] Yamauchi T. et al.(2001) Nat Med. 7:941-946. [4] Xu A. et al. (2003) J Clin Invest, 112:91-100. [5] Okamoto Y. et al. (2002) Circulation. 106:2767-2770. [6] Wang Y. et al. (2002) J Biol Chem. 277:19521-19529. [7] Xu A. et al. (2005) J Biol Chem. 280:18073-18080. [8] Maeda N. et al. (2001) Diabetes. 50:2094-2099.

Product References :

Journal American Heart Association 2013 [2(1):e004176]; Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2457-64

more info or order :

Toronto BioScience product webpage