Mouse FGF-21 Polyclonal Antibody | Toronto BioScience 12180 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Mouse FGF-21 Polyclonal Antibody

catalog :

12180

quantity :

100 μg

price :

233 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, ELISA

more info or order :

Toronto BioScience product webpage

citations: 4

Reference
Zhen E, Jin Z, Ackermann B, Thomas M, Gutierrez J. Circulating FGF21 proteolytic processing mediated by fibroblast activation protein. Biochem J. 2016;473:605-14 pubmed publisher
Zhang W, Chu S, Ding W, Wang F. Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction. PLoS ONE. 2015;10:e0129791 pubmed publisher
Samms R, Murphy M, Fowler M, Cooper S, Emmerson P, Coskun T, et al. Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. J Endocrinol. 2015;227:37-47 pubmed publisher
Ribas F, Villarroya J, Hondares E, Giralt M, Villarroya F. FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling. Biochem J. 2014;463:191-9 pubmed publisher

product information

Catalog Number :

12180

Product Name :

Mouse FGF-21 Polyclonal Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

233 USD

list of Pubmed id :

26635356, 26294388, 26091256, 25055037

Isotype :

Rabbit IgG

Product Description :

This affinity purifed rabbit polyclonal antibody can detect circular mouse fibroblast growth factor 21 (FGF-21) by ELISA and by Western Blot.

SpeciesSummary :

Mouse specificity

Background :

Fibroblast growth factor 21(FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions1,2. In murine models, FGF-21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic β- cells3,4. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents5. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon6. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance7.

ALTnames :

Fibroblast growth factor 21, FGF-21

Immunogen :

Recombinant full-length mouse FGF-21 expressed in E.Coli.

Specificity :

Mouse

Buffer :

Solution in PBS

Uses :

ELISA - This antibody can be used at 2 μg/mL with the appropriate secondary reagents to detect mouse FGF-21. Western blot - This antibody can be used at 0.2μg/mL~0.5μg/mL with the appropriate secondary reagents to detect mouse FGF-21.

Application Summary :

Storage :

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

General References :

[1] Kharitonenkov A, et al. (2005) J Clin Invest; 115: 1627– 1635. [2] Badman MK, Pissios P, et al. (2007) Cell Metab; 5: 426– 437. [3] Nishimura T, et al. (2000) Biochim Biophys Acta; 1492: 203– 206. [4] Kurosu H, et al. (2007) J Biol Chem; 282: 26687– 26695. [5] Kharitonenkov A, et al. (2005) J. Clin. Invest; 115: 1627–35. [6] Kharitonenkov, et al. (2007) Endocrinology; 148:774-81. [7] Chavez AO, et al. (2009) Diabetes Care; 32:1542-6.

Product References :

Diabetes. 2014 Dec;63(12):4064-75.

more info or order :

Toronto BioScience product webpage