Adiponectin (mouse), rabbit polyclonal | Toronto BioScience 12010 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Adiponectin (mouse), rabbit polyclonal

catalog :

12010

quantity :

100 μg

price :

194 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

more info or order :

Toronto BioScience product webpage

citations: 5

Reference
Liu Y, Palanivel R, Rai E, Park M, Gabor T, Scheid M, et al. Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice. Diabetes. 2015;64:36-48 pubmed publisher
Hui X, Gu P, Zhang J, Nie T, Pan Y, Wu D, et al. Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Cell Metab. 2015;22:279-90 pubmed publisher
Liu Y, Sen S, Wannaiampikul S, Palanivel R, Hoo R, Isserlin R, et al. Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action. Biochem J. 2015;469:71-82 pubmed publisher
Xu A, Sweeney G. Emerging role of autophagy in mediating widespread actions of ADIPOQ/adiponectin. Autophagy. 2015;11:723-4 pubmed publisher
Dadson K, Turdi S, Boo S, Hinz B, Sweeney G. Temporal and Molecular Analyses of Cardiac Extracellular Matrix Remodeling following Pressure Overload in Adiponectin Deficient Mice. PLoS ONE. 2015;10:e0121049 pubmed publisher

product information

Catalog Number :

12010

Product Name :

Adiponectin (mouse), rabbit polyclonal

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

194 USD

list of Pubmed id :

26166748, 25915851, 25910275, 25905437, 25071026

Isotype :

Rabbit IgG

Product Description :

This rabbit polyclonal antibody can detects three types of circular mouse/rat adiponectin and monomer (30kDa) adiponectin by ELISA and by Western Blot.

CrossReactivity :

Rat

SpeciesSummary :

Mouse specificity

Background :

Adiponectin, also termed gelatin-binding protein-28 (GBP28), AdipoQ, ACP30 (Acrp30), or apM, is a major adipocyte-secreted adipokine which abundantly present in the circulation as three distinct oligomeric complexes: LMW(67kDa), MMW(167kDa) and HMW(300kDa) adiponectin. Its levels are decreased in insulin resistant, diabetes and cardiovascular disease. Conversely, elevation of circulating adiponectin concentrations can alleviate various vascular dysfunctions in animal models, suggesting this adipokine exerts vasculoprotective effects. In addition, adiponectin may also be of importance in the development and progression of several malignancies.

ALTnames :

Adiponectin is also known as apM1, Acrp30, GBP28 and adipoQ.

Immunogen :

Recombinant full-length mouse adiponectin expressed in mammalian cells

Specificity :

Mouse & Rat

Buffer :

Solution in PBS

Uses :

Western blot - This antibody can be used at 0.1 – 0.2 μg/mL with the appropriate secondary reagents to detect mouse/rat adiponectin. ELISA - This antibody can be used at 0.5 - 1.0 μg/mL with the appropriate secondary reagents to detect mouse/rat adiponectin.

Application Summary :

Storage :

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

General References :

[1] Xu A, et al. (2005) Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J. Biol. Chem. 280, 18073–18080 [2] Xu A, et al. (2008) Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice. Endocrinology. [Epub ahead of print] [3] Xu A, et al. (2004) Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology. 145(2):487-94 [4] Wang Y, et al. (2008) Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J. 409(3):623-33

Product References :

Cell Metabolism 2013 [17(5):779-89], Cell Metabolism 2015 Aug 4;22(2):279-90, Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15810-5

more info or order :

Toronto BioScience product webpage