Cystatin C (human), rabbit polyclonal | Toronto BioScience 11240 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Cystatin C (human), rabbit polyclonal

catalog :

11240

quantity :

100 μg

price :

194 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA

more info or order :

Toronto BioScience product webpage

citations: 4

Reference
Xu Y, Ding Y, Li X, Wu X. Cystatin C is a disease-associated protein subject to multiple regulation. Immunol Cell Biol. 2015;93:442-51 pubmed publisher
Zethelius B, Berglund L, Sundstrom J, Ingelsson E, Basu S, Larsson A, et al. Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med. 2008;358:2107-16 pubmed publisher
Stevens L, Coresh J, Schmid C, Feldman H, Froissart M, Kusek J, et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis. 2008;51:395-406 pubmed publisher
Mi W, Pawlik M, Sastre M, Jung S, Radvinsky D, Klein A, et al. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet. 2007;39:1440-2 pubmed

product information

Catalog Number :

11240

Product Name :

Cystatin C (human), rabbit polyclonal

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

194 USD

list of Pubmed id :

18480203, 18026100, 18295055, 25643616

Isotype :

Rabbit IgG

Product Description :

This rabbit polyclonal antibody can detect circular and uric human Cystatin C by ELISA.

SpeciesSummary :

Human specificity

Background :

Human cystatin C (or cystatin 3), which is composed of 120 amino acid residues, belongs to the cystatins superfamilly that inactivates lysosomal cysteine proteinases. As a strongly cationic and low-molecular weight (13.4 kDa) protein, it is almost freely filtered across the glomerular membrane, and is mainly used as a biomarker of kidney function. A growing body of evidence suggests that cystatin C is a more reliable biomarker of glomerular filtration rate than creatinine [1-3]. In addition to kidney disease, altered serum levels of cystatin C are associated with several types of cardiovascular disease, including myocardial infarction, stroke, heart failure, peripheral arterial disease and metabolic syndrome [4-7]. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease [8, 9]. Furthermore, Cystatin C has also been investigated as a prognostic marker in several forms of cancer [11, 12].

ALTnames :

Cystatin C (CST3) is also known as ARMD11; HEL-S-2

Immunogen :

Native protein isolated from human urine

Specificity :

Human

Buffer :

Solution in PBS

Uses :

ELISA - This antibody can be used at 2μg/mL with the appropriate secondary reagents to detect human Cystatin C.

Application Summary :

ELISA - This antibody can be used at 2μg/mL with the appropriate secondary reagents to detect human Cystatin C.

Storage :

Store at –20°C.

General References :

[1] Stevens LA, Coresh J, Schmid CH, et al. (2008) Am J Kidney Dis. 51:395–406. [2] Dharnidharka VR, Kwon C, Stevens G. (2002) Am. J. Kidney Dis. 40 (2): 221–6. [3] Hermida J, Tutor JC. (2006) Ther Drug Monit. 28 (3): 326–31. [4] Zethelius B, Berglund L, Sundström J, et al. (2008) N. Engl. J. Med. 358 (20): 2107–16. [5] Ix JH, Shlipak MG, Chertow GM, Whooley MA. (2007) Circulation 115 (2): 173–9. [6] Deo R, Fyr CL, Fried LF, et al. (January 2008) Am. Heart J. 155 (1): 62–8. [7] Servais A, Giral P, Bernard M, et al. (2008) Am. J. Med. 121 (5): 426–32. [8]Mi W, Pawlik M, Sastre M, et al. (2007) Nat. Genet. 39 (12): 1440–2. [9] Kaeser SA, Herzig MC, Coomaraswamy J, et al. (2007) Nat. Genet. 39 (12): 1437–9. [10] Zurdel J, Finckh U, Menzer G, et al. (2002) Br J Ophthalmol 86 (2): 214–9. [11] Strojan P, Oblak I, Svetic B, et al. (2004) Br. J. Cancer 90 (10): 1961–8. [12] Kos J, Krasovec M, Cimerman N, et al. (2000) Clin. Cancer Res. 6 (2): 505–11.

more info or order :

Toronto BioScience product webpage