FGF-21 (human), rabbit polyclonal | Toronto BioScience 11180 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

FGF-21 (human), rabbit polyclonal

catalog :

11180

quantity :

100 μg

price :

233 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

more info or order :

Toronto BioScience product webpage

citations: 3

Reference
Youm Y, Horvath T, Mangelsdorf D, Kliewer S, Dixit V. Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. Proc Natl Acad Sci U S A. 2016;113:1026-31 pubmed publisher
Singhal G, Fisher F, Chee M, Tan T, El Ouaamari A, Adams A, et al. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS ONE. 2016;11:e0148252 pubmed publisher
Badman M, Pissios P, Kennedy A, Koukos G, Flier J, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007;5:426-37 pubmed

product information

Catalog Number :

11180

Product Name :

FGF-21 (human), rabbit polyclonal

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

233 USD

list of Pubmed id :

26872145, 26755598, 17550778

Isotype :

Rabbit IgG

Product Description :

This rabbit polyclonal antibody can detect human FGF-21 by ELISA, when conjugated to biotin.

SpeciesSummary :

Human specificity

Background :

Fibroblast growth factor 21(FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions1,2. In murine models, FGF-21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic β-cells3,4. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet- induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents5. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon6. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance7.

ALTnames :

Fibroblast growth factor 21, FGF-21

Immunogen :

Recombinant full-length human FGF-21 expressed in E.Coli.

Specificity :

Human

Buffer :

Solution in PBS

Uses :

ELISA- When conjugating to biotin, the antibody can be used as detection antibody.

Application Summary :

ELISA- When conjugating to biotin, the antibody can be used as detection antibody.

Storage :

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

General References :

[1] Kharitonenkov A, Shiyanova TL, et al. (2005) J Clin Invest; 115: 1627– 1635 [2] Badman MK, Pissios P, et al. (2007) Cell Metab; 5: 426– 437 [3] Nishimura T, Nakatake Y, et al. (2000) Biochim Biophys Acta; 1492: 203– 206 [4] Kurosu H, Choi M, et al. (2007) J Biol Chem; 282: 26687– 26695 [5] Kharitonenkov A, Shiyanova TL, et al. (2005) J. Clin. Invest. 115: 1627–35. [6] Kharitonenkov A, Wroblewski VJ, et al. (2007) Endocrinology;148:774-81 [7] Chavez AO, Molina-Carrion M, et al. (2009) Diabetes Care; 32:1542-6.

Product References :

Cell Metabolism 2013 [17(5):779-89]

more info or order :

Toronto BioScience product webpage