Plasminogen activator inhibitor type-1 (human), rabbit polyclonal | Toronto BioScience 11070 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Plasminogen activator inhibitor type-1 (human), rabbit polyclonal

catalog :

11070

quantity :

100 μg

price :

181 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA

more info or order :

Toronto BioScience product webpage

citations: 4

Reference
Marudamuthu A, Shetty S, Bhandary Y, Karandashova S, Thompson M, Sathish V, et al. Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrotic lungs. J Biol Chem. 2015;290:9428-41 pubmed publisher
Daniel A, Timmerman I, Kovacevic I, Hordijk P, Adriaanse L, Paatero I, et al. Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking. PLoS ONE. 2015;10:e0145684 pubmed publisher
Jacobs M. A review of the development of an ergonomically balanced chair. J Manipulative Physiol Ther. 1987;10:335-6 pubmed
Xu K, Liu X, Yang F, Cui D, Shi Y, Shen C, et al. PAI-1 -675 4G/5G polymorphism in association with diabetes and diabetic complications susceptibility: a meta-analysis study. PLoS ONE. 2013;8:e79150 pubmed publisher

product information

Catalog Number :

11070

Product Name :

Plasminogen activator inhibitor type-1 (human), rabbit polyclonal

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

181 USD

list of Pubmed id :

26714278, 25648892, 24223897, 3437240

Isotype :

Rabbit IgG

Product Description :

This rabbit polyclonal antibody can detect human plasminogen activator inhibitor type-1 (PAI-1) by ELISA.

SpeciesSummary :

Human specificity

Background :

Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activator, playing a major role in fibrinolysis. PAI-1 is mainly produced by the endothelium, but is also secreted by other tissue types, such as adipose tissue. It is normally present at low levels in plasma and tissue, but its expression and release increased in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome. PAI-1 is also involved in the pathophysiology of renal, pulmonary, cardiovascular, and metabolic diseases. Elevated local or systemic PAI-1 can also exacerbate such pathologic conditions.

ALTnames :

Plasminogen activator inhibitor-1 (PAI-1), also known as PAI, PAI1, PLANH1, and SERPINE1

Immunogen :

Recombinant full-length human PAI-1 expressed in E.coli.

Specificity :

Human

Buffer :

Solution in PBS

Uses :

ELISA - This antibody can be used in ELISA with the appropriate secondary reagents to detect human PAI-1

Application Summary :

ELISA - This antibody can be used in ELISA with the appropriate secondary reagents to detect human PAI-1

Storage :

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

General References :

1. Plasminogen activator inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-related subclinical and clinical conditions. Cesari M, Pahor M, Incalzi RA. Cardiovasc Ther. 2010 28(5):e72-91. 2. The plasminogen activation system: new targets in lung inflammation and remodeling. Schuliga M, Westall G, Xia Y, Stewart AG. Curr Opin Pharmacol. 2013 13(3):386-93

more info or order :

Toronto BioScience product webpage