Human Lipocalin 2 Polyclonal Antibody | Toronto BioScience 11050 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Human Lipocalin 2 Polyclonal Antibody

catalog :

11050

quantity :

100 μg

price :

194 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

more info or order :

Toronto BioScience product webpage

citations: 4

Reference
Srisawat N, Praditpornsilpa K, Patarakul K, Techapornrung M, Daraswang T, Sukmark T, et al. Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand. PLoS ONE. 2015;10:e0143367 pubmed publisher
Xu G, Ahn J, Chang S, Eguchi M, Ogier A, Han S, et al. Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation. J Biol Chem. 2012;287:4808-17 pubmed publisher
Leng X, Ding T, Lin H, Wang Y, Hu L, Hu J, et al. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res. 2009;69:8579-84 pubmed publisher
Chan Y, Liu J, Pociask D, Zheng M, Mietzner T, Berger T, et al. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol. 2009;182:4947-56 pubmed publisher

product information

Catalog Number :

11050

Product Name :

Human Lipocalin 2 Polyclonal Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

194 USD

list of Pubmed id :

22117066, 26629810, 19887608, 19342674

Isotype :

Rabbit IgG

Product Description :

This affinity purifed rabbit polyclonal antibody can detect human lipocalin 2 (LCN2) by ELISA and by Western Blot.

SpeciesSummary :

Human specificity

Background :

As described in the product data sheet, lipocalin-2(LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), 24p3, or neutrophil lipocalin (NL), is a 25-kDa secretory glycoprotein1. LCN2 has been implicated in a variety of cellular processes including the innate immune response, differentiation, tumorigenesis, and cell survival2,3. It appears to be upregulated in various inflammation and infection conditions. Several reports suggest4 that LCN2 may represent a sensitive biomarker for various renal injuries and is associated with several types of cancers, including breast cancer5, ovarian, colorectal, and pancreatic cancers6,7. Furthermore, a growing body of evidence suggests that serum levels of lipocalin-2 are correlated with obesity, insulin resistance, hyperglycemia, coronary heart disease and fatty liver disease in humans8-11.

ALTnames :

Lipocalin-2(LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), 24p3, or neutrophil lipocalin (NL)

Immunogen :

Recombinant full-length human LCN2 expressed in E.coli.

Specificity :

Human

Buffer :

Solution in PBS

Uses :

Western blot - This antibody can be used as primary antibody to detect human LCN2. ELISA - This antibody can be used in ELISA with the appropriate secondary reagents to detect human LCN2.

Application Summary :

Western blot - This antibody can be used as primary antibody to detect human LCN2. ELISA - This antibody can be used in ELISA with the appropriate secondary reagents to detect human LCN2.

Storage :

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

General References :

[1] Kjeldsen, L. et al. (1993) J. Biol. Chem. 268:10425-32 [2] Yang, J. et al. (2002) Mol. Cell. 10:1045-56. [3] Flo, T.H. et al. (2004) Nature 432:917-21. [4] Mishra, J. et al. (2005) Lancet 365:1231-6. [5] Yang, J. et al. (2009) Proc Natl Acad Sci U S A 106(10):3913-8. [6] Hanai, J. et al. (2005) J. Biol. Chem. 280:13641-7. [7] Lee, H.J. et al. (2005) Int. J. Cancer 118:2490-7. [8] Wang Y, et al. (2007) Clin Chem 53(1):34-41. [9] Yan QW, et al. (2007) Diabetes 56(10):2533-40. [10] Ruby LC Hoo, et al. (2008) Expert Rev. Endocrinol Metal 3(1):29-41. [11] Milner KL, et al. Hepatology [Epub ahead of print]

Product References :

PLoS One 2013 [8(6):e66607], Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2457-64

more info or order :

Toronto BioScience product webpage