Adiponectin (human), rabbit polyclonal | Toronto BioScience 11010 product information

product summary

company name :

Toronto BioScience

product type :

antibody

product name :

Adiponectin (human), rabbit polyclonal

catalog :

11010

quantity :

100 μg

price :

194 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

more info or order :

Toronto BioScience product webpage

citations: 5

Reference
Hui X, Gu P, Zhang J, Nie T, Pan Y, Wu D, et al. Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Cell Metab. 2015;22:279-90 pubmed publisher
Liu Y, Sen S, Wannaiampikul S, Palanivel R, Hoo R, Isserlin R, et al. Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action. Biochem J. 2015;469:71-82 pubmed publisher
Jahng J, Turdi S, Kovacevic V, Dadson K, Li R, Sweeney G. Pressure Overload-Induced Cardiac Dysfunction in Aged Male Adiponectin Knockout Mice Is Associated With Autophagy Deficiency. Endocrinology. 2015;156:2667-77 pubmed publisher
Liu Y, Palanivel R, Rai E, Park M, Gabor T, Scheid M, et al. Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice. Diabetes. 2015;64:36-48 pubmed publisher
Aye I, Rosario F, Powell T, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015;112:12858-63 pubmed publisher

product information

Catalog Number :

11010

Product Name :

Adiponectin (human), rabbit polyclonal

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Purified

Product Type :

Antibody

Size :

100 μg

List Price (USD) :

194 USD

list of Pubmed id :

26417088, 26166748, 25915851, 25961840, 25071026

Isotype :

Rabbit IgG

Product Description :

This rabbit polyclonal antibody can detect three types of circular human adiponectin and monomer (30kDa) adiponectin by ELISA and by Western Blot.

SpeciesSummary :

Human specificity

Background :

Adiponectin, also termed gelatin-binding protein-28 (GBP28), AdipoQ, ACP30 (Acrp30), or apM, is a major adipocyte-secreted adipokine which abundantly present in the circulation as three distinct oligomeric complexes: LMW(67kDa), MMW(167kDa) and HMW(300kDa) adiponectin. Its levels are decreased in insulin resistant, diabetes and cardiovascular disease. Conversely, elevation of circulating adiponectin concentrations can alleviate various vascular dysfunctions in animal models, suggesting this adipokine exerts vasculoprotective effects. In addition, adiponectin may also be of importance in the development and progression of several malignancies.

ALTnames :

Adiponectin is also known as apM1, Acrp30, GBP28 and adipoQ.

Immunogen :

Recombinant full-length human adiponectin expressed in mammalian cells

Specificity :

Human

Buffer :

Solution in PBS

Uses :

Western blot - This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect human adiponectin. ELISA - This antibody can be used at 0.5 - 1.0 μg/mL with the appropriate secondary reagents to detect human Adiponectin.

Application Summary :

Storage :

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

General References :

[1] Xu A, et al. (2005) Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J. Biol. Chem. 280, 18073–18080 [2] Xu A, et al. (2008) Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice. Endocrinology. [Epub ahead of print] [3] Xu A, et al. (2004) Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology. 145(2):487-94 [4] Wang Y, et al. (2008) Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J. 409(3):623-33

Product References :

Journal American Heart Association 2013 [2(1):e004176]; Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2457-64; Endocrinology. 145(2):487-94

more info or order :

Toronto BioScience product webpage