product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
NX 1607
catalog :
8950/10
quantity :
10 mg (also 50 mg)
price :
209 USD
more info or order :
Tocris Bioscience product webpage
product information
brand :
Tocris
catalog number base :
8950
SKU :
8950/10
product name :
NX 1607
units size :
10 mg (also 50 mg)
description :
CBL-B intramolecular glue inhibitor
target :
Molecular Glues
category :
Small Molecules
purity :
98%
observed molecular weight :
537.63
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NX 1607 (Cbl-b-IN-3) is an inhibitor of CBL-B (Casitas B-lineage lymphoma proto-oncogene B), a RING-type E3 ubiquitin ligase. NX 1607 acts as an intramolecular glue. In vitro , NX 1607 activates MAPK/ERK signaling pathway and enhances T-cell activation in primary T cells and Jurkat T cells. In vivo , NX 1607 decreases tumor growth in cell lymphoma models. NX 1607 is orally bioavailable.
top caption :
CBL-B intramolecular glue inhibitor
extended description :
CBL-B intramolecular glue inhibitor
chemical name text :
2,3-Dihydro-2-[3-[cis-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-6-[[(3S)-3-methyl-1-piperidinyl]methyl]-4-(trifluoromethyl)-1H-isoindol-1-one
formula :
C30H34F3N5O
formula text :
C30H34F3N5O
cas num :
2573775-59-2
USD :
209 USD
product details :
CBL-B intramolecular glue inhibitor
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK