product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
CCS 1477
catalog :
8892/10
quantity :
10 mg
price :
219 USD
more info or order :
Tocris Bioscience product webpage
product information
brand :
Tocris
catalog number base :
8892
SKU :
8892/10
product name :
CCS 1477
units size :
10 mg
description :
Selective p300/CBP bromodomain inhibitor
target :
Bromodomain Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
534.61
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CCS 1477 is a selective p300/CBP bromodomain inhibitor. CCS 1477 binds with high affinity to p300 and CBP (Kd values are 1.3 and 1.7 nM, respectively), and with 170/130-fold selectivity compared with BRD4 (Kd = 222 nM). In vitro , CCS 1477 inhibits the proliferation of OPM-2 multiple myeloma cells (GI50 = 5 nM). Also, CCS 1477 inhibits cell proliferation in prostate cancer cell lines and decreases AR- and C-MYC-regulated gene expression. In vivo , CCS 1477 significantly improves survival and reduces tumor size in MOLM16 AML and OPM2 myeloma tumors in subcutaneous xenograft models. CCS 1477 is orally bioavailable.
top caption :
Selective p300/CBP bromodomain inhibitor
extended description :
Selective p300/CBP bromodomain inhibitor
chemical name text :
(6S)-1-(3,4-Difluorophenyl)-6-[5-(3,5-dimethyl-4-isoxazolyl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]-2-piperidinone
formula :
C30H32F2N4O3
formula text :
C30H32F2N4O3
cas num :
2222941-37-7
USD :
219 USD
product details :
Selective p300/CBP bromodomain inhibitor
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK