8856/5 | Tocris Bioscience 8856/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8856/5

catalog :

8856/5

quantity :

5 mg

price :

299 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

8856

SKU :

8856/5

product name :

NX 5948

unit size :

5 mg

description :

Potent and selective BTK Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

806.97

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NX 5948 is a potent and selective Bruton s tyrosine kinase (BTK) Degrader (PROTAC ) (DC50 = 1 nM; Dmax = 98%). Comprises a BTK binding moiety joined by a linker to cereblon (CRBN) ligand. In vitro , NX-5948 very potently, rapidly and completely degrades BTK in primary human B cells (DC50 = 0.034 nM). NX 5948 degrades BTK, inhibits tumor growth and increases survival in TMD8 xenograft mouse models of brain maligancy. Reduces inflammation and symptom severity in a mouse model of collagen-induced arthritis. NX 5948 is orally bioavailable and blood brain barrier penetrant. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Selective BTK Degrader

extended description :

Potent and selective BTK Degrader (PROTAC )

chemical name text :

3-[[4-[1-[[1-[6-[[[(3S)-2,6-Dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-2-pyrazinecarboxamide

formula :

C42H54N12O5

formula text :

C42H54N12O5

cas num :

2649400-34-8

USD :

299 USD

product details :

Potent and selective BTK Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage