product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
8842/10
catalog :
8842/10
quantity :
10 mg (also 50 mg)
price :
143 USD
more info or order :
Tocris Bioscience product webpage
product information
master code :
8842
SKU :
8842/10
product name :
BI 4394
unit size :
10 mg (also 50 mg)
description :
Highly potent and selective MMP-13 inhibitor
target :
Synthetic Metalloprotease Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
446.46
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
BI 4394 is a highly potent and selective MMP-13 inhibitor (IC50 = 1 nM). BI 4394 inhibits the degradation of isolated bovine nasal cartilage explants (IC50 = 31 nM). It shows high selectivity (>1000 fold) for MMP-13 over other MMPs. In vivo , BI 4394 decreases the mean arthritic score vs control in a murine model of rheumatoid arthritis, when administered at a dose of 100 mg/kg over a 14-day period. BI 4394 is orally bioavailable.
top caption :
Highly potent and selective MMP-13 inhibitor
extended description :
Highly potent and selective MMP-13 inhibitor
chemical name text :
2-Ethyl 5-[3-[[[(4-carboxyphenyl)methyl]amino]carbonyl]-1-methyl-1H-pyrazol-5-yl]-1H-indole-2-carboxylate
formula :
C24H22N4O5
formula text :
C24H22N4O5
cas num :
1222173-37-6
USD :
143 USD
product details :
Highly potent and selective MMP-13 inhibitor
storage :
Store at -20░C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK