product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
AZ 3137
catalog :
8833/5
quantity :
5 mg
price :
319 USD
more info or order :
Tocris Bioscience product webpage
product information
brand :
Tocris
catalog number base :
8833
SKU :
8833/5
product name :
AZ 3137
units size :
5 mg
description :
Potent and selective AR and AR L702H Degrader, orally bioavailable
target :
Active Degraders
category :
Small Molecules
purity :
98%
observed molecular weight :
801.89
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
AZ 3137 is a potent and selective androgen receptor (AR) Degrader (PROTAC )(DC50 = 22 nM in LNCaP cells). AZ 3137 can degrade L702H mutant AR (DC50 = 158 nM). AZ 3137 inhibits the proliferation of LNCaPs cells (GI50 = 74 nM). AZ 3137 inhibits AR signaling in vitro and tumor growth in vivo in a mouse prostate cancer xenograft model. AZ 3137 is orally bioavailable.
top caption :
Potent and selective AR and AR L702H Degrader, orally bioavailable
extended description :
Potent and selective AR and AR L702H Degrader, orally bioavailable
chemical name text :
4-[4-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-7-methoxy-1-oxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]phenyl]-1-piperidinyl]-3-fluoro-2-(trifluoromethyl)benzonitrile
formula :
C43H47F4N7O4
formula text :
C43H47F4N7O4
cas num :
2960179-55-7
USD :
319 USD
product details :
Potent and selective AR and AR L702H Degrader, orally bioavailable
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK