product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
8811/10
catalog :
8811/10
quantity :
10 mg (also 50 mg)
price :
169 USD
more info or order :
Tocris Bioscience product webpage
product information
master code :
8811
SKU :
8811/10
product name :
ESI 1
unit size :
10 mg (also 50 mg)
description :
Selective HDAC3 inhibitor; also myelination inducer
target :
Class I Histone Deacetylases Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
392.28
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ESI 1 (epigenetic silencing inhibitor 1; also called PT3) is an HDAC3 inhibitor (IC50 = 250 nM). ESI 1 exhibits high selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8. Also, ESI 1 promotes remyelination in demyelinated animal models and enables de novo myelinogenesis on regenerated CNS axons. In vivo , ESI 1 enhances long-term memory in mouse model of novel object recognition. ESI 1 triggers nuclear condensate formation of lipid-metabolic regulators SREBP1/2, concentrating transcriptional co-activators to drive lipid/cholesterol biosynthesis. ESI 1 is orally bioavailable and blood-brain-barrier penetrant.
top caption :
Selective HDAC3 inhibitor; also myelination inducer
extended description :
Selective HDAC3 inhibitor; also myelination inducer
chemical name text :
N-(2-Aminophenyl)-5-[(phenylmethyl)amino]-2-pyrazinecarboxamide dihydrochloride
formula :
C18H17N5O.2HCl
formula text :
C18H17N5O.2HCl
USD :
169 USD
product details :
Selective HDAC3 inhibitor; also myelination inducer
storage :
Store at -20░C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK