chemical

VT 104

8176/10

10 mg (also 50 mg)

140 USD

8176

8176/10

VT 104

10 mg (also 50 mg)

Potent pan-TEAD inhibitor

YAP1

Small Molecules

98%

420.43

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VT 104 is a potent pan-TEAD (transcriptional enhanced associate domain) inhibitor (IC50 = 10.4 nM). VT 104 inhibits YAP/TAZ-TEAD promoted gene transcription by preventing the association between YAP/TAZ and TEAD. VT 104 blocks TEAD auto-palmitoylation. In vitro , VT 104 inhibits NF2-deficient mesothelioma cell proliferation, and growth of subcutaneous tumor xenografts in vivo . VT 104 is orally bioavailable.

Potent pan-TEAD inhibitor

Potent pan-TEAD inhibitor

N-[(1S)-1-(2-Pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide

C25H19F3N2O

C25H19F3N2O

2417718-25-1

140 USD

Potent pan-TEAD inhibitor

65 kDa Yes-associated protein, COB1, Protein Yorkie Homolog, Transcriptional Coactivator YAP1, WWTR1, YAP, YAP1-2gamma, YAP2, YAP2L, YAP65, YAP65yes-associated protein 2, Yes Associated Protein, Yes-Associated Protein, Yes-associated protein 1, Yes-associated protein 1, 65kDa, yes-associated protein beta, yes-associated protein delta, Yes-Associated Protein YAP65 Homolog, YKI, Yorkie Homolog

Store at -20°C