8152/2 | Tocris Bioscience 8152/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8152/2

catalog :

8152/2

quantity :

2 mg

price :

379 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

8152

SKU :

8152/2

product name :

JQ dS-4

unit size :

2 mg

description :

BRG1/SMARCA4 Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

95%

observed molecular weight :

719.16

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JQ dS-4 is a Brahma-related gene 1 (BRG1)/BRM/SMARCA4 Degrader (PROTAC DC50 range = 9 - 390 nM in glioma models and cell lines). Comprises a BRG1 inhibitor joined by a linker to a cereblon (CRBN) E3 ligase ligand. Completely degrades BRG1 after 48 and 72 hours in HSJD-DIPG007 and SU-DIPGXIIIP cells and reduces viability of a variety of cancer cell lines including H3K27M glioma, prostate, thyroid and salivary gland. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

BRG1/SMARCA4 Degrader (PROTAC )

extended description :

BRG1/SMARCA4 Degrader (PROTAC )

chemical name text :

3-((4-(3-(2-Chloropyridin-4-yl)ureido)pyridin-2-yl)ethynyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)benzamide

formula :

C37H31ClN8O6

formula text :

C37H31ClN8O6

cas num :

2688882-69-9

USD :

379 USD

product details :

BRG1/SMARCA4 Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage