8141/5 | Tocris Bioscience 8141/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8141/5

catalog :

8141/5

quantity :

5 mg

price :

169 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

8141

SKU :

8141/5

product name :

SJ 3149

unit size :

5 mg

description :

Potent and selective CK1 molecular glue Degrader

target :

Molecular Glues

category :

Small Molecules

purity :

98%

observed molecular weight :

376.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SJ 3149 is a potent and selective CK1 molecular glue Degrader (DC50 = 3.7 nM; Dmax 95% in MOLM-13 cells). SJ 3149 induced near-complete degradation of the CK1 protein (DC50 = 6 nM at 4 hours). Potently inhibits the viability of MOLM-13 cells (IC50 = 13 nM). SJ 3149 displays a broad antiproliferative activity profile on a panel of acute leukemia and solid tumor cell lines. In vivo , SJ 3149 degrades CK1 protein levels in NSG mice transplanted with MOLM-13 cells. SJ 3149 shows 76% orally bioavailability.

top caption :

Potent and selective CK1 molecular glue Degrader

extended description :

Potent and selective CK1 molecular glue Degrader

chemical name text :

3-(5-(Benzo[d]isoxazol-3-ylamino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

formula :

C20H16N4O4

formula text :

C20H16N4O4

cas num :

3026986-17-1

USD :

169 USD

product details :

Potent and selective CK1 molecular glue Degrader

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage