8118/5 | Tocris Bioscience 8118/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8118/5

catalog :

8118/5

quantity :

5 mg

price :

309 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent NSD2 Degrader

product information

master code :

8118

SKU :

8118/5

product name :

UNC 8732

unit size :

5 mg

description :

Potent NSD2 Degrader

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

723.75

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UNC 8732 is a potent nuclear receptor binding SET domain-containing 2 (NSD2) Degrader (DC50 = 60 nM; Dmax = 97%). NSD2 degradation is driven by the aldehyde metabolite of UNC 8732 in vitro . Recruits FBX022 and SCF complexes for degradation to reduce H3K36me2 levels in cells. Reduces viability and restores glucocorticoid sensitivity of NSD2 p.E1099K mutant ALL cells.

top caption :

Potent NSD2 Degrader

extended description :

Potent NSD2 Degrader

chemical name text :

N-[[4-[[[2-(6-Amino-1-oxohexyl)-1,2,3,4-tetrahydro-6-isoquinolinyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-7-carboxamide trifluoroacetate

formula :

C35H39N5O5.CF3CO2H

formula text :

C35H39N5O5.CF3CO2H

cas num :

2929304-06-1

USD :

309 USD

product details :

Potent NSD2 Degrader

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage