product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
8116/5
catalog :
8116/5
quantity :
5 mg
price :
379 USD
more info or order :
Tocris Bioscience product webpage
product information
master code :
8116
SKU :
8116/5
product name :
PPM-3
unit size :
5 mg
description :
Potent and selective ERK5 Degrader (PROTAC )
target :
Active Degraders
category :
Small Molecules
purity :
98%
observed molecular weight :
1000.28
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
PPM-3 is a potent and selective ERK5 Degrader (PROTAC ) (IC50 = 62.4 nM). PPM-3 degrades ERK5 in HCT116, h1975, HepG2, MDA-MB-231, PC-3, and A375 tumor cell lines (DC50 values are 5.6, 11.5, 13.7, 22.7, 23.5 and 41.4 nM respectively). PPM-3 has no effect on tumor cell growth directly but influences tumor development by affecting the differentiation of macrophages.
top caption :
Potent and selective ERK5 Degrader (PROTAC )
extended description :
Potent and selective ERK5 Degrader (PROTAC )
chemical name text :
(2S,4R)-1-((S)-2-(7-(4-(4-((5,11-Dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carbo
formula :
C54H69N11O6S
formula text :
C54H69N11O6S
cas num :
3032388-42-1
USD :
379 USD
product details :
Potent and selective ERK5 Degrader (PROTAC )
storage :
Store at -20░C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK