product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
8113/5
catalog :
8113/5
quantity :
5 mg
price :
329 USD
more info or order :
Tocris Bioscience product webpage
product information
master code :
8113
SKU :
8113/5
product name :
BAY 593
unit size :
5 mg
description :
Geranylgeranyltransferase-I (GGTase-I) inhibitor
target :
Other Transferase Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
513
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
BAY 593 is a geranylgeranyltransferase-I (GGTase-I) inhibitor. Blocks activation of Rho-GTPases to inactivate YAP1/TAZ signaling. Dose-dependently inhibits growth of tumors in xenograft mouse models (IC50 values are 38.4 nM and 564 nM in MT-1080 and MDA-MB-231 cells respectively) and PXF 541 xenografts. Orally bioavailable and suitable for use in vivo .
top caption :
Geranylgeranyltransferase-I (GGTase-1) inhibitor
extended description :
Geranylgeranyltransferase-I (GGTase-I) inhibitor
chemical name text :
(2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride
formula :
C26H31F3N2O3.HCl
formula text :
C26H31F3N2O3.HCl
cas num :
2413020-57-0
USD :
329 USD
product details :
Geranylgeranyltransferase-I (GGTase-I) inhibitor
storage :
Store at -20░C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK