chemical

8106/10

8106/10

10 mg (also 50 mg)

179 USD

8106/10

WNTinib

10 mg (also 50 mg)

Inhibitor of mutant -catenin signaling in hepatocellular carcinoma

beta-Catenin

Small Molecules

98%

498.39

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WNTinib is a multi-kinase inhibitor with selectivity for mutant -catenin (CTNNB1) in hepatocellular carcinoma compared to wild type hepatocytes (IC50 ranges are 0.36 M-0.54 M in primary organoids; 0.28 M-1 M in primary human HCC cell lines and 0.45 M-2.3 M in human cell lines ). Also inhibits VEGFR2, PDE6D and VEGFR1 (IC50 values are 0.3 M, 0.3 M and 0.6 M respectively). Downregulates WNT and phospho-EZH2, upregulates trimethylation of H3K27 and normalises expression of apoptotic genes.

Inhibitor of mutant -catenin signaling in hepatocellular carcinoma

Inhibitor of mutant -catenin signaling in hepatocellular carcinoma

4-[3-Fluoro-4-[[[[4-(1,1,2,2,2-pentafluoroethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide

C22H16F6N4O3

C22H16F6N4O3

2770091-44-4

179 USD

Inhibitor of mutant -catenin signaling in hepatocellular carcinoma

bCatenin, beta 1 (88kD), beta-catenin, catenin (cadherin-associated protein), beta 1, 88kDa, catenin beta-1, CD309, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, Flk1, Flk-1, Flt-1, FLT1, FRT, GMP-PDE delta, KDR, KRD1, Ly73, PDED, Protein p17, VEGF R1, VEGF R2, VEGFR-1

Store at -20░C