8105/10 | Tocris Bioscience 8105/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8105/10

catalog :

8105/10

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective CDKL5 inhibitor

product information

master code :

8105

SKU :

8105/10

product name :

CAF 382

unit size :

10 mg (also 50 mg)

description :

Potent and selective CDKL5 inhibitor

target :

CDKL5

category :

Small Molecules

purity :

98%

observed molecular weight :

480.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CAF 382 is potent and selective CDKL5 (cyclin-dependent kinase-like 5) inhibitor (IC50 = 10 nM). Exhibits nearly 100-fold selectivity for CDKL5 over CDKL2, low inhibition for CDKL3 and CDKL4 (IC50 = 2.1-2.7 ?M), and no inhibition for CDKL1. CAF 382 lacks GSK3 activity. It causes a significant reduction in pSer222 EB2 at 5 nM without a change in total EB2 levels in rat primary cortical neuron cultures. CAF 382 is an analog of SNS 032 (Cat. No. 4075).

top caption :

Potent and selective CDKL5 inhibitor

extended description :

Potent and selective CDKL5 inhibitor

chemical name text :

N-[5-[(5-Propan-2-yl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide trifluoroacetate

formula :

C16H22N4O2S2.CF3CO2H

formula text :

C16H22N4O2S2.CF3CO2H

USD :

195 USD

product details :

Potent and selective CDKL5 inhibitor

alt names :

cyclin-dependent kinase-like 5, serine/threonine kinase 9, serine/threonine-protein kinase 9, STK9

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage