8093/10 | Tocris Bioscience 8093/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8093/10

catalog :

8093/10

quantity :

10 mg (also 50 mg)

price :

205 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective EZH2 inhibitor

product information

master code :

8093

SKU :

8093/10

product name :

Tazemetostat

unit size :

10 mg (also 50 mg)

description :

Potent and selective EZH2 inhibitor

target :

EZH2 Inhibitor

category :

Small Molecules

purity :

97%

observed molecular weight :

572.74

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Tazemetostat is a potent and selective EZH2 inhibitor (Ki = 2.5 nM; IC50 = 11 nM). Reduces H3K27me3 levels in PDX derived cells and inhibits cellular H3K27 methylation. Tazemetostat suppresses EZH2 and MYC expression and induces neuronal differentiation genes; also increases neurite extension in MB-39-nu cells. Antiproliferative in SMARCAB1-deleted MRT cell lines (IC50 = 32 - 1000 nM); inhibits methylation in both mutant and wild type cells (IC50 = 1.4-4.9 nM). Dose-dependently suppresses growth of both MC38 cells and tumors in vivo .

top caption :

Potent and selective EZH2 inhibitor

extended description :

Potent and selective EZH2 inhibitor

chemical name text :

N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4 -(4-morpholinylmethyl)[1,1 -biphenyl]-3-carboxamide

formula :

C34H44N4O4

formula text :

C34H44N4O4

cas num :

1403254-99-8

USD :

205 USD

product details :

Potent and selective EZH2 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage