8083/5 | Tocris Bioscience 8083/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8083/5

catalog :

8083/5

quantity :

5 mg

price :

399 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Selective class I HDAC Degrader (PROTAC )

product information

master code :

8083

SKU :

8083/5

product name :

JPS016

unit size :

5 mg

description :

Selective class I HDAC Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

97%

observed molecular weight :

898.13

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JSP016 is a selective Degrader (PROTAC ) and inhibitor of class I HDACs (DC50 values are 530 nM and 550 nM for HDAC3 and HDAC1; Dmax is 77%, 66% and 45% at HDAC1, 3 and 2; IC50 values are 380 nM, 570 nM and 820 nM at HDAC3, 1 and 2). Comprises a benzamide-based compound joined by a linker to a Von Hippel Lindau (VHL) E3 ligase ligand. JPS016 treatment up- or down-regulates nearly 4000 differentially expressed genes, arrests cells at sub-G1 phase and promotes apoptosis in HCT116 cells.

top caption :

Selective class I HDAC Degrader (PROTAC )

extended description :

Selective class I HDAC Degrader (PROTAC )

chemical name text :

(2S,4R)-1-((S)-2-(2-((9-(2-((4-((2-Aminophenyl)carbamoyl)phenyl)amino)-2-oxoethoxy)nonyl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C48H63N7O8S

formula text :

C48H63N7O8S

cas num :

2669785-77-5

USD :

399 USD

product details :

Selective class I HDAC Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage