8081/5 | Tocris Bioscience 8081/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8081/5

catalog :

8081/5

quantity :

5 mg

price :

349 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

8081

SKU :

8081/5

product name :

MS 143

unit size :

5 mg

description :

AKT kinase Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

97%

observed molecular weight :

1121.89

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MS 143 is a potent and selective protein kinase B (AKT) Degrader (PROTAC ) (DC50 = 46 nM, Dmax = 100 % at 24h in PC3 cells). MS 143 suppresses growth in prostate cancer PC3 cells; suppresses tumor growth and reduces AKT protein levels in a mouse PC3 cell xenograft model. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

AKT kinase Degrader (PROTAC )

extended description :

AKT kinase Degrader (PROTAC )

chemical name text :

4-Amino-N-((S)-1-(4-chlorophenyl)-3-(4-(12-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecanoyl)piperazin-1-yl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4

formula :

C59H81ClN12O6S

formula text :

C59H81ClN12O6S

cas num :

2376137-41-4

USD :

349 USD

product details :

AKT kinase Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage