8080/2 | Tocris Bioscience 8080/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8080/2

catalog :

8080/2

quantity :

2 mg

price :

349 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

8080

SKU :

8080/2

product name :

MS 4322

unit size :

2 mg

description :

Selective PRMT5 Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1101.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MS 4322 is a protein arginine methyltransferase 5 (PRMT5) Degrader (PROTAC ) (DC50 = 1.1 M, Dmax = 74% in MCF-7 cells). Also inhibits PRMT5 methyltransferase activity (IC50 = 18 nM) and dose-dependently inhibits proliferation of HeLa, A549, A172 and Jurkat cancer cell lines. Comprises a PRMT5 inhibitor linked to an E3 ligase ligand. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Selective PRMT5 Degrader (PROTAC )

extended description :

Selective PRMT5 Degrader (PROTAC )

chemical name text :

N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amin

formula :

C55H76N10O12S

formula text :

C55H76N10O12S

cas num :

2375432-47-4

USD :

349 USD

product details :

Selective PRMT5 Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage