8077/2 | Tocris Bioscience 8077/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8077/2

catalog :

8077/2

quantity :

2 mg

price :

245 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

PRC1 Degrader (PROTAC degrades BMI1 and RING1B

product information

master code :

8077

SKU :

8077/2

product name :

MS 147

unit size :

2 mg

description :

PRC1 Degrader (PROTAC degrades BMI1 and RING1B

target :

Active Degraders

category :

Small Molecules

purity :

97%

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MS 147 is a polycomb repressive complex 1 (PRC1) Degrader (PROTAC ) (Kd values are 450 nM and 3 M for VHL and EED, respectively). Comprises an EED binder ( EED 226, Cat. No. 7762) joined by a linker to a VHL E3 ligase ligand. MS 147 preferentially degrades BMI1 and RING1B and reduces H2AK119ub in K562 cells. Inhibits proliferation in cancer cell lines that are insensitive to EZH2 knockout or EED/PRC2 Degraders. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

PRC1 Degrader (PROTAC degrades BMI1 and RING1B

extended description :

PRC1 Degrader (PROTAC degrades BMI1 and RING1B

chemical name text :

(2S,4R)-1-((S)-2-(7-(5-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)pentanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

formula :

C54H70N12O6S.xHCl

formula text :

C54H70N12O6S.xHCl

USD :

245 USD

product details :

PRC1 Degrader (PROTAC degrades BMI1 and RING1B

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage