8073/5 | Tocris Bioscience 8073/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8073/5

catalog :

8073/5

quantity :

5 mg

price :

179 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

8073

SKU :

8073/5

product name :

MS 6105

unit size :

5 mg

description :

Potent lactate dehydrogenase Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1228.6

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MS 6105 is a potent and selective lactate dehydrogenase (LDH) Degrader (PROTAC for LDHA and LDHB respectively, DC50 values are 38 nM and 74 nM; Dmax is 93% and 86%). Comprises an LDH inhibitor warhead connected by a linker to a VHL ligand. Suppresses growth of several pancreatic cancer cell lines (IC50 range is 12.2 M - 16.1 M). Bioavailable in vivo . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Potent lactate dehydrogenase Degrader (PROTAC )

extended description :

Potent lactate dehydrogenase Degrader (PROTAC )

chemical name text :

2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-ca

formula :

C65H81N9O9S3

formula text :

C65H81N9O9S3

cas num :

2891709-58-1

USD :

179 USD

product details :

Potent lactate dehydrogenase Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage