8072/10 | Tocris Bioscience 8072/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8072/10

catalog :

8072/10

quantity :

10 mg

price :

225 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

product information

master code :

8072

SKU :

8072/10

product name :

FK 866

unit size :

10 mg

description :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

target :

NAMPT Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

391.51

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FK 866 is a non-competitive and high-affinity inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by Etoposide (Cat. No. 1226) and Cisplatin (Cat. No. 2251).

top caption :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

extended description :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

chemical name text :

(2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide

formula :

C24H29N3O2

formula text :

C24H29N3O2

cas num :

658084-64-1

USD :

225 USD

product details :

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage