8063/5 | Tocris Bioscience 8063/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8063/5

catalog :

8063/5

quantity :

5 mg

price :

319 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Liu L, Malagu K, Haughan A, Khetarpal V, Stott A, Esmieu W, et al. Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease. J Med Chem. 2023;66:13205-13246 pubmed publisher

image

image 1 :

Potent HTT pre-RNA splicing modulator.

product information

master code :

8063

SKU :

8063/5

product name :

CHDI 113

unit size :

5 mg

description :

Potent HTT pre-RNA splicing modulator

target :

Huntingtin

category :

Small Molecules

purity :

98%

observed molecular weight :

395.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CHDI 113 is a potent huntingtin ( HTT ) pre-mRNA splicing modulator (EC50 = 66 nM). It lowers HTT protein in both human Huntington s disease (HD) stem cells and in the brain of BACHD (bacterial artificial chromosome-mediated transgenic) mouse model. CHDI 113 is brain penetrant and orally bioavailable.

top caption :

Potent HTT pre-RNA splicing modulator.

extended description :

Potent HTT pre-RNA splicing modulator

chemical name text :

5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide

formula :

C20H22FN7O

formula text :

C20H22FN7O

cas num :

2743336-70-9

USD :

319 USD

product details :

Potent HTT pre-RNA splicing modulator

alt names :

HD, HD protein, HTT, huntingtin, huntingtin (Huntington disease), IT15, IT15HDHuntington disease protein

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage