8057/10 | Tocris Bioscience 8057/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8057/10

catalog :

8057/10

quantity :

10 mg

price :

215 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Schulte M, Fu A, Zhao P, Li J, Geng L, Smith S, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat Med. 2018;24:194-202 pubmed publisher

product information

master code :

8057

SKU :

8057/10

product name :

V 9302 hydrochloride

unit size :

10 mg

description :

ASCT2 (SLC1A5) inhibitor

target :

Other Ion Pump/Transporter Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

575.15

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

V 9302 hydrochloride is an alanine-serine-cysteine transporter 2 (ASCT2, encoded by gene SLC1A5) inhibitor. It inhibits glutamate uptake (IC50 = 9.6 M in HEK-293 cells). It reduces cancer cell growth and proliferation, also increases cell death and oxidative stress in vitro and in vivo . V 9302 hydrochloride inhibits mTORC1 activity, mitochondrial respiration, proliferation and migration of vascular smooth muscle cells (VSMCs).

top caption :

ASCT2 (SLC1A5) inhibitor

extended description :

ASCT2 (SLC1A5) inhibitor

chemical name text :

(2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid hydrochloride

formula :

C34H38N2O4.HCl

formula text :

C34H38N2O4.HCl

cas num :

2416138-42-4

USD :

215 USD

product details :

ASCT2 (SLC1A5) inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage