8023/10 | Tocris Bioscience 8023/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8023/10

catalog :

8023/10

quantity :

10 mg (also 50 mg)

price :

275 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Mer/Axl Dual inhibitor

product information

master code :

8023

SKU :

8023/10

product name :

AZ 14145845

unit size :

10 mg (also 50 mg)

description :

Dual Mer/Axl inhibitor

target :

Additional RTK Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

561.69

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZ 14145845 is a potent, and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively). In vivo , AZ 14145845 shows dose-dependent reduction of tumor growth in the Mer and Axl kinase Ba/F3 tumor xenograft model. AZ 14145845 combined with anti-PD1 antibodies and ionizing radiation increases survival in mice with tumors derived from MC38 cells in vivo . AZ 14145845 is orally bioavailable.

top caption :

Mer/Axl Dual inhibitor

extended description :

Dual Mer/Axl inhibitor

chemical name text :

3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine-6-methanamine

formula :

C32H35N9O

formula text :

C32H35N9O

cas num :

2830555-70-7

USD :

275 USD

product details :

Dual Mer/Axl inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage