8018/5 | Tocris Bioscience 8018/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8018/5

catalog :

8018/5

quantity :

5 mg

price :

249 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

8018

SKU :

8018/5

product name :

142D6

unit size :

5 mg

description :

Potent Lys-covalent pan-IAP inhibitor

target :

IAP Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

552.66

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

142D6 is a potent pan-IAP inhibitor (IC50 values are 21, 21 and 43 nM for cIAP1, cIAP2 and XIAP respectively). 142D6 covalently targets Lys residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family. In vitro , 142D6 reduces viability of cultured breast cancer MDA-MB-231 cells (EC50 values are 44 and 61 nM in cell viability and apoptosis assays, respectively). 142D6 is chemically stable in buffer and plasma and is orally bioavailable.

top caption :

Potent Lys-covalent pan-IAP antagonist

extended description :

Potent Lys-covalent pan-IAP inhibitor

chemical name text :

(R)-1-((S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-2,3-dihydro-1H-inden-4-yl sulfurofluoridate

formula :

C26H37FN4O6S

formula text :

C26H37FN4O6S

cas num :

2410953-19-2

USD :

249 USD

product details :

Potent Lys-covalent pan-IAP inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage