8007/10 | Tocris Bioscience 8007/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

8007/10

catalog :

8007/10

quantity :

10 mg (also 50 mg)

price :

139 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Selective and potent inhibitor of both mouse and human THIK-1

product information

master code :

8007

SKU :

8007/10

product name :

C 101248

unit size :

10 mg (also 50 mg)

description :

Selective and potent inhibitor of both mouse and human THIK-1

target :

Two-P Potassium Channels Blockers

category :

Small Molecules

purity :

98%

observed molecular weight :

292.3

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

C 101248 is a selective and potent inhibitor of both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50 = 50 nM); it exhibits no activity against K2P family members, TREK-1 and TWIK-2, and Kv2.1. C 101248 blocks both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of mouse hippocampal microglia. C 101248 reduces neuroinflammation by preventing NLRP3-dependent release of IL-1 in isolated microglia.

top caption :

Selective and potent inhibitor of both mouse and human THIK-1

extended description :

Selective and potent inhibitor of both mouse and human THIK-1

chemical name text :

4-[1-(4-Pyridinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine

formula :

C15H12N6O

formula text :

C15H12N6O

cas num :

361368-24-3

USD :

139 USD

product details :

Selective and potent inhibitor of both mouse and human THIK-1

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage