7990/5 | Tocris Bioscience 7990/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7990/5

catalog :

7990/5

quantity :

5 mg (also 25 mg)

price :

209 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Molecular glue Degrader of mutant -catenin

product information

master code :

7990

SKU :

7990/5

product name :

NRX 252114

unit size :

5 mg (also 25 mg)

description :

Molecular glue Degrader of mutant -catenin

target :

Molecular Glues

category :

Small Molecules

purity :

98%

observed molecular weight :

510.31

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NRX-252114 is a potent enhancer of the interaction between S37A mutant -catenin, and its cognate E3 ligase, SCF -TrCP (EC50 = 6.5 nM; Kd = 0.4 nM). NRX-252114 is a molecular glue degrader that binds at the phosphoserine binding site on -TrCP and induces mutant -catenin ubiquitination and subsequent degradation.

top caption :

Molecular glue Degrader of mutant -catenin

extended description :

Molecular glue Degrader of mutant -catenin

chemical name text :

2-[[4-[(2,6-Dichlorophenyl)thio]-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-pyridinyl]carbonyl]-2,3-dihydro-1H-isoindole-4-carbonitrile

formula :

C22H12Cl2F3N3O2S

formula text :

C22H12Cl2F3N3O2S

cas num :

2763260-39-3

USD :

209 USD

product details :

Molecular glue Degrader of mutant -catenin

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage