7983/5 | Tocris Bioscience 7983/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7983/5

catalog :

7983/5

quantity :

5 mg

price :

389 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

IRAK3 PROTAC Degrader

product information

master code :

7983

SKU :

7983/5

product name :

IRAK3 Degrader 23

unit size :

5 mg

description :

IRAK3 Degrader (PROTAC

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

878.09

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IRAK3 Degrader 23 is a potent and selective IRAK3 Degrader (PROTAC DC50 = 2 nM; Dmax = 98% in THP1 cells and primary macrophages), requires CRBN and IRAK3 binding for Degrader activity. Also inhibits CDK11, CDK8, TRKC and GSG2 (IC50 values are 16 nM, 36 nM, 100 nM and 110 nM respectively). . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

IRAK3 PROTAC Degrader

extended description :

IRAK3 Degrader (PROTAC

chemical name text :

2-(2,6-Dioxo-3-piperidyl)-5-[4-[2-[1-[4-[4-[cis-4-[(5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]-piperazin-1-yl]-4-oxo-butanoyl]-4-piperidyl]ethyl]piperazin-1-yl]-isoindoline-1,3-dione

formula :

C47H63N11O6

formula text :

C47H63N11O6

cas num :

2712600-00-3

USD :

389 USD

product details :

IRAK3 Degrader (PROTAC

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage