7981/10 | Tocris Bioscience 7981/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7981/10

catalog :

7981/10

quantity :

10 mg (also 50 mg)

price :

79 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent pan-HDAC inhibitor

product information

master code :

7981

SKU :

7981/10

product name :

Belinostat

unit size :

10 mg (also 50 mg)

description :

Potent pan-HDAC inhibitor

target :

Histone Deacetylase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

318.35

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Belinostat is a potent pan-HDAC inhibitor (IC50 = 28 nM). Dose-dependently reduces tumor volume in a rat model of glioblastoma and induces 70% and 28% apoptosis in LN-229 and LN-18 glioma cell lines (IC50 values are 210 nM and 300 nM respectively). In H358 cells, Belinostat dose-dependently reduces cell viability and upregulates amino acids and metabolites of the TCA and urea cycle. Also potently inhibits C4 release from stem cell-derived astrocytes and shows antidepressant activity. Belinostat is brain penetrant.

top caption :

Potent pan-HDAC inhibitor

extended description :

Potent pan-HDAC inhibitor

chemical name text :

(2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide

formula :

C15H14N2O4S

formula text :

C15H14N2O4S

cas num :

866323-14-0

USD :

79 USD

product details :

Potent pan-HDAC inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage