7980/10 | Tocris Bioscience 7980/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7980/10

catalog :

7980/10

quantity :

10 mg (also 50 mg)

price :

145 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

PINK1 activator

product information

master code :

7980

SKU :

7980/10

product name :

MTK 458

unit size :

10 mg (also 50 mg)

description :

PINK1 activator

target :

PINK1

category :

Small Molecules

purity :

98%

observed molecular weight :

332.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MTK 458 is a brain penetrant PTEN-induced kinase 1 (PINK1) activator. It binds to and stabilizes the active form of PINK1, increasing its activity and activating mitophagy downstream. It mediates clearance of pathogenic -synuclein and normalizes pS65-Ubiquitin (pUb) in in vivo Parkinson s models. MTK458 is orally bioavailable.

top caption :

PINK1 activator

extended description :

PINK1 activator

chemical name text :

N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

formula :

C17H15F3N4

formula text :

C17H15F3N4

cas num :

2499962-58-0

USD :

145 USD

product details :

PINK1 activator

alt names :

BRPK, EC 2.7.11.1, FLJ27236, PARK6, Parkinson disease (autosomal recessive) 6, protein kinase BRPK, PTEN Induced Kinase 1, PTEN induced putative kinase 1, PTEN-induced putative kinase protein 1, serine/threonine-protein kinase PINK1, mitochondrial

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage