chemical

7963/10

7963/10

10 mg (also 50 mg)

115 USD

7963/10

PFI 653

10 mg (also 50 mg)

Potent and selective vanin 1 inhibitor

Vanin-1/VNN1

Small Molecules

98%

354.41

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PFI 653 is a potent and selective vanin 1 inhibitor (IC50 values in the range 6.85 - 24.5 nM). The compound exhibits selectivity over a panel of 40 kinases and a selection of 35 other targets including enzymes, receptors and ion channels (IC50 vs biotinidase > 50 M). Following administration of a single dose of PFI 653 (2 mg/kg iv) in rats AUC is 1790 ng.h/mL, half-life is 1 h and clearance is 19 mL/min/kg. Following oral administration of PFI 653 in solution, bioavailablility is 96%. In mice with DSS-induced inflammatory bowel disease (IBD), oral adminstration of PFI 653 dose-dependently reduces vanin 1 enzyme activity and disease symptoms.

Potent and selective vanin 1 inhibitor

Potent and selective vanin 1 inhibitor

8-Oxa-2-azaspiro[4.5]dec-2-yl[2-[(2-pyrazinylmethyl)amino]-5-pyrimidinyl]methanone

C18H22N6O2

C18H22N6O2

2173134-00-2

115 USD

Potent and selective vanin 1 inhibitor

EC 3.5.1, EC 3.5.1.92, HDLCQ8, MGC116930, MGC116931, MGC116932, pantetheinase, Pantetheine hydrolase, Tiff66, Tiff66MGC116933, vanin 1, vanin-1, Vanin1, vannin 1, Vascular non-inflammatory molecule 1, VNN1

Store at -20░C