product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
7960/10
catalog :
7960/10
quantity :
10 mg (also 50 mg)
price :
95 USD
more info or order :
Tocris Bioscience product webpage
product information
master code :
7960
SKU :
7960/10
product name :
PFI 7
unit size :
10 mg (also 50 mg)
description :
Selective GID4 antagonist
target :
Ubiquitin Ligase (E3) Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
474.43
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
PFI 7 is a selective GID4 antagonist (Kd = 80 nM by SPR assays and EC50 = 0.6 M by cell-based NanoBRET). PFI 7 binds within the ?-barrel of GID4 substrate binding pocket, disrupting its interaction with the canonical Pro/N-degron peptide in live cells. It alters protein levels of several proteins including RNA helicases as measured by quantitative proteomics.
top caption :
GID4 antagonist
extended description :
Selective GID4 antagonist
chemical name text :
N-((1s,4s)-4-(1H-Benzo[d]imidazol-2-yl)cyclohexyl)-2-(((1H-indol-2-yl)methyl)amino)acetamide dihydrochloride
formula :
C24H27N5O.2HCl
formula text :
C24H27N5O.2HCl
USD :
95 USD
product details :
Selective GID4 antagonist
storage :
Store at -20░C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK