chemical

7945/100

7945/100

100 mg

105 USD

7945/100

Cholesterol

100 mg

Component of lipid nanoparticles (LNPs); modulator of lipid bilayer fluidity

Lipid Nanoparticles

Small Molecules

95%

386.65

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Cholesterol is a major sterol in all mammalian organisms; it is an essential component that makes up about 20-25% of the structural lipids of cell membranes. Cholesterol determines the permeability and fluidity characteristics of the cell membranes. Cholesterol is an endogenous ligand for estrogen-related receptor (ERR ). It is also a precursor in several biosynthetic pathways, including steroid hormones and the active form of vitamin D. Cholesterol is a component of lipid nanoparticles (LNPs), and is important in modulating membrane stability, with the effect being context dependent. When combined with lipids that have low gel-liquid crystalline phase transition temperature (Tm), Cholesterol reduces membrane fluidity and increases bilayer thickness; when combined with high Tm lipids, it increases membrane fluidity and narrows the bilayer thickness. . For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol . For a fully formulate LNP containing DLin-MC3-DMA and a luciferase mRNA reporter, see MC3 LNP Luciferase (Cat. No. 8889).

Component of lipid nanoparticles (LNPs); modulator of lipid bilayer fluidity

Component of lipid nanoparticles (LNPs); modulator of lipid bilayer fluidity

(3 )-Cholest-5-en-3-ol

C27H46O

C27H46O

57-88-5

105 USD

Component of lipid nanoparticles (LNPs); modulator of lipid bilayer fluidity

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