7940/5 | Tocris Bioscience 7940/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7940/5

catalog :

7940/5

quantity :

5 mg

price :

399 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

7940

SKU :

7940/5

product name :

HEMTAC 26

unit size :

5 mg

description :

CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

target :

Active Degraders

category :

Small Molecules

purity :

95%

observed molecular weight :

953.51

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

HEMTAC 26 is a potent HSP90-mediated targeting chimera (HEMTAC) that degrades CDK6 and CDK4 (DC50 values are 19 nM and 26 nM; Dmax = 92% and 88% in B16F10 cells, 36h treatment). HEMTAC 26 inhibits growth of a range of cancer cell lines including B16F10 and A375 (IC50 values are 112 nM and 126 nM respectively). Induces cell cycle arrest at G0/G1 phase in B16F10 cells.

top caption :

CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

extended description :

CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

chemical name text :

4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[[1-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-3-butyn-1-yl]-1H-1,2,3-triazol-4-yl]methyl]-

formula :

C48H53ClN16O4

formula text :

C48H53ClN16O4

cas num :

2821803-61-4

USD :

399 USD

product details :

CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage