chemical

7917/10

7917/10

10 mg (also 50 mg)

135 USD

7917/10

TM2 TEAD inhibitor

10 mg (also 50 mg)

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

YAP1

Small Molecules

98%

435.57

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TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo .

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide

C26H33N3O3

C26H33N3O3

1008768-41-9

135 USD

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

65 kDa Yes-associated protein, COB1, Protein Yorkie Homolog, Transcriptional Coactivator YAP1, YAP, YAP1-2gamma, YAP2, YAP2L, YAP65, YAP65yes-associated protein 2, Yes Associated Protein, Yes-Associated Protein, Yes-associated protein 1, Yes-associated protein 1, 65kDa, yes-associated protein beta, yes-associated protein delta, Yes-Associated Protein YAP65 Homolog, YKI, Yorkie Homolog

Store at -20░C