7916/10 | Tocris Bioscience 7916/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7916/10

catalog :

7916/10

quantity :

10 mg (also 50 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Selective SMN2 gene splicing modifier

product information

master code :

7916

SKU :

7916/10

product name :

Risdiplam

unit size :

10 mg (also 50 mg)

description :

Selective SMN2 gene splicing modifier

target :

DNA, RNA and Protein Synthesis Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

401.47

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Risdiplam is a selective survival of motor neuron-2 (SMN2) pre-mRNA splicing modifier. It potently enhances SMN2 splicing in vitro (EC1.5X = 4 nM) and increases SMN protein in both brain (up to 100%) and muscle tissues (up to 49%) of transgenic mouse models of spinal muscular atrophy (SMA). Risdiplam dose-dependently increases the number of vesicular glutamate transporter 1 (vGlut1) proprioceptive inputs on motor neurons, the number of L3 to L5 motor neurons, the percentage of fully innervated neuromuscular junctions, and muscle size in the extensor digitorum longus muscles in SMN 7 mice.

top caption :

Selective SMN2 gene splicing modifier

extended description :

Selective SMN2 gene splicing modifier

chemical name text :

7-(4,7-Diazaspiro[2.5]oct-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

formula :

C22H23N7O

formula text :

C22H23N7O

cas num :

1825352-65-5

USD :

169 USD

product details :

Selective SMN2 gene splicing modifier

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage