7904/10 | Tocris Bioscience 7904/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7904/10

catalog :

7904/10

quantity :

10 mg (also 50 mg)

price :

234 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

product information

master code :

7904

SKU :

7904/10

product name :

RU.521

unit size :

10 mg (also 50 mg)

description :

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

target :

Synthase/Synthetase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

415.23

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM; IC50 values are 0.11 M and 2.94 M against m-cGAS and h-cGAS, respectively). RU.521 suppresses dsDNA-activated reporter activity but not 5 ppp-HP20 RNA or murine IFN- -induced IFN- 1-dependent gene expression. RU.521 reduces constitutive expression of type I interferon in primary macrophages from a mouse model of Aicardi-Gouti?res syndrome. Pretreatment of chimeric antigen receptor (CAR) redirected T cells with RU.521 increases efficiency of virus-free gene editing by improving cell viability and CAR integration in cell line.

top caption :

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

extended description :

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

chemical name text :

3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-1(3H)-isobenzofuranone

formula :

C19H12Cl2N4O3

formula text :

C19H12Cl2N4O3

cas num :

2262452-06-0

USD :

234 USD

product details :

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

alt names :

RU320521

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage