7902/10 | Tocris Bioscience 7902/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7902/10

catalog :

7902/10

quantity :

10 mg (also 50 mg)

price :

147 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

product information

master code :

7902

SKU :

7902/10

product name :

PIK 90

unit size :

10 mg (also 50 mg)

description :

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

target :

PI 3-Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

351.36

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PIK 90 is a potent inhibitor of PI 3-K / / kinases (IC50 = 11, 18, 47, 58 and 64 nM against p110 , p110 , PI 3-KC2 , p110 and PI 3-KC2 , respectively) as well as PIKKs (IC50 = 13 nM against DNA-PK). It inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells. It suppresses insulin-stimulated phosphorylation of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in vitro and prevents insulin-induced blood glucose reduction in mice in vivo . PIK 90 can be used in combination with other small molecules and proteins for mesendoderm induction in protocols to differentiate iPSCs into organ-specific mesenchyme.

top caption :

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

extended description :

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

chemical name text :

N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

formula :

C18H17N5O3

formula text :

C18H17N5O3

cas num :

677338-12-4

USD :

147 USD

product details :

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage