7891/10 | Tocris Bioscience 7891/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7891/10

catalog :

7891/10

quantity :

10 mg (also 50 mg)

price :

140 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent FLT3 inhibitor; also potently inhibits AXL

product information

master code :

7891

SKU :

7891/10

product name :

Gilteritinib

unit size :

10 mg (also 50 mg)

description :

Potent FLT3 inhibitor; also potently inhibits AXL

target :

Flt-3/Flk-2

category :

Small Molecules

purity :

98%

observed molecular weight :

552.71

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Gilteritinib is a potent Fms-like tyrosine kinase 3 (FLT3) and AXL inhibitor (IC50 = 0.29 nM and 0.73 nM, for FLT3 and AXL, respectively). In vivo , Gilteritinib reduces tumor growth and improves survival in xenograft and intra-bone marrow transplantation models of FLT3 mutated acute myeloid leukemia. Gilteritinib is orally bioavailable.

top caption :

Potent FLT3 inhibitor; also potently inhibits AXL

extended description :

Potent FLT3 inhibitor; also potently inhibits AXL

chemical name text :

6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide

formula :

C29H44N8O3

formula text :

C29H44N8O3

cas num :

1254053-43-4

USD :

140 USD

product details :

Potent FLT3 inhibitor; also potently inhibits AXL

alt names :

AI323647, ARK, CD135, CD135 antigen, EC 2.7.10, fetal liver kinase 2, FL cytokine receptor, Flk-2, FLK2, Flt3, FLT-3, FLT3 receptor tyrosine kinase, Fms-like tyrosine kinase 3, fms-related tyrosine kinase 3, growth factor receptor tyrosine kinase type III, JTK11, Stem cell tyrosine kinase 1, STK-1, STK1EC 2.7.10.1, Tyro7, Tyrosine-protein kinase receptor FLT3, UFO

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage